Your Number Story

The Science
of ACEs

Dr. Moshe Szyf's TED Talk: How early life experience is written into DNA

Dr. Moshe Szyf is a pioneer in epigenetics who is doing groundbreaking work on the biochemical signals passed from mothers to their offspring. Watch this video to learn how, as Dr. Szyf says, “DNA isn’t just a sequence of letters, it’s a dynamic movie in which our experiences are being written.”

Roadmap for Resilience: Intergenerational Transmission of Adversity

This section of the California Surgeon General’s Roadmap for Resilience lays out the generational impact of ACEs and toxic stress. 

Here's a summary of the main points:

INTERGENERATIONAL TRANSMISSION

ACEs and toxic stress can alter the biology and behavior of people in ways that affect the birth and development of their children.

GENERATIONAL RISK

Children born to parents with high ACE scores are more likely to experience a variety of neuropsychiatric, behavioral, and physical health problems.

PRENATAL IMPACTS

The effects of toxic stress due to ACEs may impact our ability to conceive, and may increase risk of miscarriage, preterm birth, and low birth weight.

ADVERSITY AND RESILIENCE CAN BE PASSED ON THROUGH EPIGENETICS

The intergenerational transmission of ACEs isn’t fully determined in childhood. The same pathways that pass on the negative effects of toxic stress can also pass on positive resiliency factors when we as adults with ACEs adopt long-term practices to heal ourselves, and are supported by communities and systems with resources that address our needs.

Graphic of holding hands, symbolizing reaching out to peers for help

Help us with your feedback on this 3-question survey!

What brings you to this site today?

1 of 3

How has this site been helpful to you?

2 of 3

How likely are you to recommend this site to someone in your life?

3 of 3

Thank you for sharing your experience!