What happens when two powerhouse leaders team up to address one of the most pressing issues of our time? Find out here in this dynamic conversation between Oprah Winfrey and Dr. Nadine Burke Harris.

Here are a few highlights …

[ OPRAH ] “The realization of what happened to you literally colors your entire worldview … Your childhood experiences don’t define you, but they do leave an imprint. You need to be aware of what that imprint is.”

[ OPRAH ] “This now becomes a conversation for the public that can actually be heard … we need to combine forces and shout it even louder.”

[ DR. BURKE HARRIS ] “ACEs are a public health crisis, and that means we need to take a public health approach.”

[ DR. BURKE HARRIS ] “Our brains and our bodies develop in response to our experiences.”

[ OPRAH ] “I think we’ve got to do a better job of helping people understand that there’s a biological stress response!”

[ DR. BURKE HARRIS ] “We have a heart — a cardiovascular system, lungs — a respiratory system … and we have a stress response system. And it can be well-regulated and healthy, or it can become dysregulated. And if it’s dysregulated, that increases our risk for physical, mental, and behavioral health disorders.”

[ OPRAH ] “Finally, we get to the root of the way people behave the way they do … When we ask that question, ‘What happened to you?’ it literally shifts the paradigm from ‘What’s wrong with you?’ to empathy and understanding.”